Prof. Dr. Joachim Steinbach

Dr. Senckenbergisches Institut für Neuroonkologie
Zentrum der Neurologie und Neurochirurgie
Schleusenweg 2-16
60528 Frankfurt

Tel 069 6301 87711
Fax 069 6301 87713

joachim.steinbachmed.uni-frankfurt.de

Homepage

Scientific Focus

- Metabolic alterations in malignant glioma
- Signal transduction
- Hypoxia-induced cell death

Methods

- Metabolic analysis (consumption of oxygen and glucose, production of lactate)
- Cell death analysis (LDH-release, flow cytometry, apoptosis assays)
- Molecular analysis (quantitative RT-PCR, reporter assays)

Selected Publications

Thiepold AL, Lorenz N, Foltyn M, Engel AL, Divé I, Urban H, Heller S, Bruns I, Hofmann U, Dröse S, Harter PN, Mittelbronn M, Steinbach JP and Ronellenfitsch MW. Mammalian target of rapamycin complex 1 activation sensitizes human glioma cells to hypoxia-induced cell death. Brain. 2017 Jun; accepted for publication*

Zhang C, Burger MC, Jennewein L, Genßler S, Schönfeld K, Zeiner P, Hattingen E, Harter PN, Mittelbronn M, Tonn T, Steinbach JP, Wels WS. ErbB2/HER2-Specific NK Cells for Targeted Therapy of Glioblastoma. J Natl Cancer Inst. 2015 Dec 6;108(5)

Rieger J, Bähr O, Maurer GD, Hattingen E, Franz K, Brucker D, Walenta S, Kämmerer U, Coy JF, Weller M, Steinbach JP. ERGO: a pilot study of ketogenic diet in recurrent glioblastoma. Int J Oncol. 2014; 44:1843-2

Wanka C, Brucker DP, Bähr O, Ronellenfitsch M, Weller M, Steinbach JP, Rieger J. Synthesis of cytochrome c oxidase 2: a p53-dependent metabolic regulator that promotes respiratory function and protects glioma and colon cancer cells from hypoxia-induced cell death. Oncogene. 2012;31:3764-76

Ronellenfitsch M, Brucker D, Burger M, Wolking S, Tritschler F, Rieger J, Wick W, Weller M, Steinbach JP. Antagonism of mTOR selectively mediates metabolic effects of EGFR inhibition and protects human malignant glioma cells from hypoxia-induced cell death. Brain. 2009;132:1509-22

Home
About us
Idea
Structure
Members
ICNF-Flyer