Prof. Dr. Dr. Achim Schmidtko
|Pharmakologisches Institut für Naturwissenschaftler
Our key research focus is on the characterization of cellular and molecular mechanisms of pain processing. Fully functional pain perception is essential to protect the human body from harmful influences. In conditions of persistent pain such as inflammation or nerve injury, pain loses its protective functions and may become a disease in its own right. Typical characteristics of persistent pain are increased response to pain stimuli (hyperalgesia), painful perception of usually non-painful stimuli (allodynia) and the development of spontaneous pain without apparent cause. This sensitization of the pain processing system poses a major therapeutic problem specifically in patients with chronic pain, and is insufficiently treatable with available medication in many cases. Our research addresses cell communication in the nociceptive system, and the messenger and receptors involved, in order to identify new targets for pain therapy. We focus on pain-relevant processes in the peripheral nervous system and the spinal cord.
• Behavioural analysis in murine animal models of acute nociceptive, inflammatory and neuropathic pain.
Kallenborn-Gerhardt W, Möser CV, Lorenz JE, Steger M, Heidler J, Scheving R, Petersen J, Kennel L, Flauaus C, Lu R, Edinger AL, Tegeder I, Geisslinger G, Heide H, Wittig I, Schmidtko A (2017) Rab7-a novel redox target that modulates inflammatory pain processing. Pain 158(7):1354-65.