Prof. Dr. med. Felix Rosenow, MHBA

Department of Neurology
Head, Epilepsy Center Frankfurt Rhine-Main
Neurocenter
Schleusenweg 2-16 (Haus 95)
60528 Frankfurt a.M.

Tel +49(0)69/6301-7466
Fax +49(0)69/6301-84466

Felix.Rosenowkgu.de

Homepage

Scientific Focus

Translational and clinical epilepsy research

Epilepsy genetics

Neurophysiology

Clinical trials

Methods

Experimental models of temporal lobe epilepsy

Neurophysiology including stereo-EEG

Genetic imaging, genetic neurophysiology

Selected Publications

Baulac M, Rosenow F, Toledo M, Terada K, Ting Li T, De Backer M, Werhahn KJ, Brock M. Efficacy, safety, and tolerability of lacosamide monotherapy versus controlled-release carbamazepine in patients with newly-diagnosed epilepsy: a phase 3, randomised, double-blind, non-inferiority trial. Lancet Neurol 2017;16(1):43-54

Reschke CR, Silva LF, Norwood BA, Senthilkumar K, Morris G, Sanz-Rodriguez A, Conroy RM, Costard L, Neubert V, Bauer S, Farrell MA, O'Brien DF, Delanty N, Schorge S, Pasterkamp RJ, Rosenow F, Henshall DC. Potent Anti-seizure Effects of Locked Nucleic Acid Antagomirs Targeting miR-134 in Multiple Mouse and Rat Models of Epilepsy. Mol Ther Nucleic Acids. 2017;6:45-56

Rajman M, Metge F, Fiore R, Khudayberdiev S, Aksoy-Aksel A, Bicker S, Ruedell-Reschke C, Raoof R, Brennan G, Delanty N, Farrell M, o´Brien D, Bauer S, Norwood B, Veno MT, Krüger M, Braun T, Kjems J, Rosenow F, Henshall D, Dieterich C, Schratt G. A microRNA-129-5p/Rbfox crosstalk coordinates homeostatic downscaling of excitatory synapses. The EMBO Journal May 2017 DOI 10.15252/embj.201695748

Raoof R, Jimenez-Mateos E, Bauer S, Tackenberg, Rosenow F, Lang J, Müjgan Dogan M, Hamer H, Huchtemann T, Körtvélyessy P, Connolly N, Pfeiffer S, Prehn J, Farrell M, O'Brien D, Henshall D, Mooney C. Cerebrospinal fluid microRNAs are potential biomarkers of temporal lobe epilepsy and status epilepticus. Scientific Reports 2017 12;7(1):3328.

Henshall DC, Hamer HM, Pasterkamp RJ, Goldstein DB, Kjems J, Prehn JH, Schorge S, Lamottke K, Rosenow F. MicroRNAs in epilepsy: pathophysiology and clinical utility. Lancet Neurol. 2016 Dec;15(13):1368-1376

Reif PS, Tsai MH, Helbig I, Rosenow F, Klein KM. Precision medicine in genetic epilepsies: break of dawn? Expert Rev Neurother. 2017;17(4):381-92

Johannesen K, Marini C, Pfeffer S, Mřller RS, Dorn T, Niturad C, Gardella E, Weber Y, Sřndergĺrd M, Hjalgrim H, Nikanorova M, Becker F, Larsen LH, Dahl HA, Maier O, Mei D, Biskup S, Klein KM, Reif PS, Rosenow F, Elias AF, Hudson C, Helbig KL, Schubert-Bast S, Scordo MR, Craiu D, Djémié T, Hoffman-Zacharska D, Caglayan H, Helbig I, Serratosa J, Striano P, De Jonghe P, Weckhuysen S, Suls A, Muru K, Talvik I, Talvik T, Muhle H, Borggraefe I, Rost I, Guerrini R, Lerche H, Lemke JR, Rubboli G, Maljevic S. Phenotypic spectrum of GABRA1: From generalized epilepsies to severe epileptic encephalopathies. Neurology. 2016 Sep 13;87(11):1140-51

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