Prof. Dr. Dr. Abdelhaq Rami
|Dr. Senckenbergische Anatomie
Institut für Zelluläre und Molekulare Anatomie
Anatomie III, Universitätsklinikum
60590 Frankfurt am MaD-in
Recent studies have suggested that pharmacological activation of autophagy offers an exciting therapeutic prospect for certain chronic neurodegenerative conditions. However, in contrast to its life-promoting role, autophagy also controls a distinct form of apoptosis and may even contribute to pathological cell death, thereby complicating its function in health and disease. Although apoptosis and autophagic cell death evoke clearly distinct features of the cell death mechanisms, the border between the two types of cell demise is not completely understood. Our research aims to screen the regulation and role of autophagy in neurons in response to cerebral ischemia. The extent of autophagy may represent a master switch between cell survival and cell death. A profound understanding of the biological effects and the mechanisms underlying ischemia-induced autophagy in neurons might be helpful in seeking effective new treatments for cerebral ischemia.
Focal and global ischemia in vivo
Rami A, Benz A. Exclusive Activation of Caspase-3 in Mossy Fibers and Altered Dynamics of Autophagy Markers in the Mice Hippocampus upon Status Epilepticus Induced by Kainic Acid. Mol Neurobiol. 2017 [Epub ahead of print] PubMed PMID: 28685385.