Prof. Dr. Karl H. Plate

Edinger Institute
Goethe University Medical School

Frankfurt, Germany

Tel (49)-[0]69-6301-6042
Fax (49)-[0]69-679487

karl-heinz.platekgu.de

Homepage

Scientific Focus

Methods

Selected Publications

1. Beck H, Acker T, Wiessner C, Allegrini PR, Plate KH. Expression of Angiopoietin-1, Angiopoietin-2 and tie receptors following middle cerebral artery occlusion in the rat. Am J Pathol 157: 1473-1483, 2000

2. Krieg M, Haas R, Brauch H, Acker T, Flamme I, Plate KH. Up-regulation of hypoxia-inducible factors HIF-1 and HIF-2 under normoxic conditions in renal carcinoma cells by von Hippel-Lindau tumor suppressor gene loss of function. Oncogene 19:5435-5443, 2000

3. Acker T, Beck H, Plate KH. Cell type specific expression of vascular endothelial growth factor and angiopoietin-1 and -2 suggests an important role of astrocytes in cerebellar vascularization. MOD 108:45-57, 2001

4. Oosthuyse B, Moons L, Storkebaum E, Beck H, Nuyens D, Brusselmans K, Dorpe JV, Hellings P, Gorselink M, Heymans S, Theilmeier G, Dewerchin M, Laudenbach V, Vermylen P, Raat H, Acker T, Vleminckx V, Bosch LV, Cashman N, Fujisawa H, Drost MR, Sciot R, Bruyninckx F, Hicklin DJ, Ince C, Gressens P, Lupu F, Plate KH, Robberecht W, Herbert JM, Collen D, Carmeliet P. Deletion of the hypoxia-response element in the vascular endothelial growth factor promoter causes motor neuron degeneration. Nature Genetics 28:131-138, 2001

5. Beck H, Acker T, Püschel W, Fujisawa H, Carmeliet P, Plate KH. Cell Type Specific Expression of Neuropilins in an MCA-Occlusion Model in Mice Suggests a Potential Role in Post-Ischemic Brain Remodeling. J Neuropath Exp Neurol 6:339-350, 2002

6. Beck H, Voswinckel R, Wagner S, Ziegelhoeffer T, Heil M, Helisch M, Schaper W, Acker T, Hatzopoulos AK, Plate KH. Participation of bone marrow-derived cells in long-term repair processes following stroke. J Cereb Blood Flow Metab 23:709-717, 2003

7. Machein MR, Renninger S, de Lima-Hahn E, Plate KH. Minor contribution of bone marrow-derived endothelial progenitors to the vascularization of murine gliomas. Brain Pathol 13: 582-597, 2003

8. Machein M, Knedla A, Knoth R, Wagner S, Neuschl E, Plate KH. Angiopoietin-1 promotes tumor angiogenesis in a rat glioma model. Am J Path. 165:1557-1570, 2004

9. Schänzer A, Wachs F-P, Wilhelm D, Acker T, Cooper-Kuhn C, Beck H, Winkler J, Aigner L, Plate KH*. Kuhn HG*. Direct stimulation of adult neural stem cells in vitro and neurogenesis in vivo by vascular endothelial growth factor. Brain Pathol 14:237-248, 2004 (* equal contribution)

10. Acker T, Diez-Juan A, Aragones J, Tjwa M, Brusselmans K, Moon L, Fukumura D, Moreno-Murciano MP, Herbert J-M, Burger B, Riedel J, Elvert G, Flamme I, Maxwell P, Collen D, Decherin M, Jain RK, Plate KH*, Carmeliet P*. Genetic evidence for a tumor suppressor role of HIF-2a. Cancer Cell 8:131-141, 2005 (* equal contribution)

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